Author's response to reviews Title: Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma Authors:
نویسندگان
چکیده
Claudia Lengerke ([email protected]) Tanja Fehm ([email protected]) Ralf Kurth ([email protected]) Hans Neubauer ([email protected]) Veit Scheble ([email protected]) Friederike Müller ([email protected]) Friederike Schneider ([email protected]) Karen Petersen ([email protected]) Diethelm Wallwiener ([email protected]) Lothar Kanz ([email protected]) Falko Fend ([email protected]) Sven Perner ([email protected]) Petra M. Bareiss ([email protected]) Annette Staebler ([email protected])
منابع مشابه
Tumor and Stem Cell Biology SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness and pluripotency in embryonic stem cells and plays important roles during early embryogenesis. More recently, SOX2 expression was documented in several tumor types including ovarian carcinoma, suggesting an involvement of SOX2 in regulation of cancer stemcells (CSC). Intriguingly, however, studies exploring t...
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Background The mammary gland in humans is a dynamic organ that undergoes significant developmental changes during pregnancy, lactation, and involution. Stem cells derived from human breast milk possess the adult stem cell-like characteristics such as self-renewal, proliferative and differentiate potential. This source of stem cells avoids invasive procedures and the ethical controversy of emb...
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Background & Aims: Nucleostemin is one of the stem cell enriched proteins which encodes a novel nucleolar GTP-binding protein found at high levels in the adult and embryonic stem (ES) cells but not in terminally differentiated cells. It is also expressed in tumor cell lines as well as in the several types of human cancers. Due to the increasing rate of breast cancer in recent years, in the pres...
متن کاملExtract of mouse embryonic stem cells induces the expression of pluripotency genes in human adipose tissue-derived stem cells
Objective(s): In some previous studies, the extract of embryonic carcinoma cells (ECCs) and embryonic stem cells (ESCs) have been used to reprogram somatic cells to more dedifferentiated state. The aim of this study was to investigate the effect of mouse ESCs extract on the expression of some pluripotency markers in human adipose tissue-derived stem cells (ADSCs). Materials and Methods: Human A...
متن کاملMolecular and functional interactions between AKT and SOX2 in breast carcinoma.
The transcription factor SOX2 is a key regulator of pluripotency in embryonic stem cells and plays important roles in early organogenesis. Recently, SOX2 expression was documented in various cancers and suggested as a cancer stem cell (CSC) marker. Here we identify the Ser/Thr-kinase AKT as an upstream regulator of SOX2 protein turnover in breast carcinoma (BC). SOX2 and pAKT are co-expressed a...
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تاریخ انتشار 2010